In conclusion, we demonstrated that miR-96-5p, miR-183-5p, and miR-210-3p counteract DCT cytotoxicity in PCa cells by regulating FOXO1, IGFBP3, PDCD4, INSIG1, and PPP2CB likely by increasing survival pathways and escaping from DCT-induced apoptosis. Here, INSIG1 is linked to posterior cortical atrophy.