CCN2 and cancer: THY-1 is expressed in fibroblasts, myofibroblasts, thymocytes, mesenchymal stem cells, cancer stem cells, ovarian cancer cells, endothelial cells, neurons, neuronal smooth muscle cells, hematopoietic cells, and plant cells.[30,31] THY1 interacts with other molecules and may function as part of a multimolecular complex, affecting several important intracellular signaling cascades.[32] CCN2 is known as a connective tissue growth factor, exists in the tissue structure and regulates cell proliferation, survival, differentiation, adhesion, migration and ECM production.