CCN2 and heart disorder: CCN2-mediated increases in ECM synthesis play a role in a variety of fibrotic diseases.[33] THY-1 regulates changes in the cell phenotype in response to external stimuli, regulates basic characteristics, such as pluripotency, differentiation and survival, and plays an important role in cell differentiation and regeneration.[31] The regulation of THY1 and CCN2 expression plays an important role in the pathogenesis of heart disease.