AKT1 and cardiac hypertrophy: Rapamycin can reduce myocardial hypertrophy, activate cardiomyocyte autophagy and reduce myocardial infarction size by inhibiting mTORC1.Rapamycin plays an anti-cardiac hypertrophy role by activating Akt, promoting protein ubiquitination, and inhibiting cardiomyocyte apoptosis and cardiac fibrosis.[28,29]