These observations indicate that Rk3 has the potential to exert cardioprotective effects against H/R injury, which may be of great importance for clinical efficacy in acute myocardial infarction (AMI) treatment.[22] Yang[23] showed that ginsenoside CK intervention could significantly reduce the levels of myocardial necrosis and infarct fiber scar, and reduce the inflammatory factors TNF-α and interleukin in the serum of AMI mice. Here, TNF is linked to myocardial infarction.