Tyrosine kinase inhibitor, such as Imatinib and Nilotinib, have been proved to be useful for cases with genetic C-KIT changes, while larotinib is useful for patients with NTRK gene fusion positive.[14–16] Our patient finally received transabdominal extensive Hysterectomy, bilateral adnexectomy, pelvic lymph node resection, left lateral rectal fossa tumor resection, pelvic severe adhesion separation and total Vaginectomy. This evidence concerns the gene KIT and neoplasm.