Long-term glucocorticoid treatment may decrease the concentration of estradiol receptor and weaken the estradiol-stimulated growth of uterus.[19] Furthermore, long-term glucocorticoid use weakens muscle and induces atrophy of smooth muscle by decreasing protein synthesis.[20,21] Emmy et al presented a UUR of multigravida pregnant woman with chronic use of glucocorticoids for the disease of psoriatic arthritis, which further proved a causal link between the chronic use of GCs and UR.[2]. The gene discussed is ESR1; the disease is psoriatic arthritis.