CD4 and fungal infectious disease: The disease is regarded as one of the most common endemic mycoses in HIV-infected patients in those areas, causing high morbidity and mortality.[4] Ninety-five percent (95%) of patients with acquired immunodeficiency syndrome (AIDS) and H capsulatum infection develop disseminated disease, with 90% having CD4 counts below 200 cells/mm3 at the time of diagnosis.[5] In the US, state-specific annual incidence rates ranged from 0 to 4.3 cases/100,000 population, with the highest rates found in cities in endemic areas, including the Ohio and Mississippi River valleys.[6]