Indeed, there are still a small number of robust studies regarding this region, even though histoplasmosis is currently considered the most prevalent endemic mycosis on the Latin American continent.[41] A high prevalence of this infection in people living with HIV has already been demonstrated in studies carried out in Brazil, French Guiana, and Guatemala, especially in those with a CD4 cell count < 50/mm3. Here, CD4 is linked to fungal infectious disease.