It is noteworthy that although prior research had established that MMP‐2 inhibitors results in inhibition of tumor invasion and angiogenesis attributable to the activity of extracellular MMP‐2,25 our study is the first to demonstrate a significant inhibition in osteosarcoma cell migration as a result of inactivating MMP‐2 gene in the presence of active extracellular MMP‐2. Here, MMP2 is linked to osteosarcoma.