AGT and cardiac hypertrophy: For instance, inhibition or knockout of xCT can exacerbate cardiomyocyte hypertrophy and angiotensin II (Ang II)-induced cardiac fibrosis in mice and increase the levels of the ferroptosis biomarkers Ptgs2, MDA and ROD, while Fer-1 can alleviate the exacerbation of cardiac hypertrophy caused by inhibiting xCT in rat cells or ablating xCT in mice [89].