Mechanistically, FEACR directly binds to nicotinamide phosphoribosyltransferase (NAMPT) to increase NAMPT-dependent Sirtuin1 (Sirt1), which promotes the transcriptional activity of forkhead box protein O1 (FOXO1), which can upregulate FTH1, leading to the amelioration of MI and improvements cardiac function by inhibiting ferroptosis [129]. Here, FOXO1 is linked to myocardial infarction.