A previous study showed that cardiac LRP6 is downregulated in patients with dilated cardiomyopathy, and cardiomyocyte-specific depletion of LRP6 causes lethal dilated cardiomyopathy, such as acute HF and cardiac dysfunction, resulting from the suppression of autophagy-mediated degradation and fatty acid utilization through Drp1/mTOR/TFEB signaling [127, 132]. Here, TFEB is linked to dilated cardiomyopathy.