Our results are also in line with the ERα-mediated anti-apoptotic effects of adenosine against Aβ25-35-induced brain damage [54] and of formononetin in AD patients [55], as well as the ER/PI3K/Akt-mediated effect of naringenin against Aβ25-35-caused damage in neuronally differentiated PC12 cells [56]. The gene discussed is ESR1; the disease is Alzheimer disease.