The anti-apoptotic properties of ER agonists have been supported by a wide variety of studies, including the beneficial actions of S-equol (ERβ agonist) on platelet mitochondria cytochrome oxidase (COX) activity in AD women [48] and neuroprotective effects exerted by a newly synthesized benzopyran FMDB (R-9-(4fluorophenyl)-3-methyl-10,10-hydrogen-6-hydrogen-benzopyran) on cognition, neurogenesis, and apoptosis in APP/PS1 transgenic mice with ERβ knockdown [49]. Here, ESR2 is linked to Alzheimer disease.