BHLHE40 is a known immune response mediator involved in infection, autoimmunity, and inflammation.[6] We previously reported that BHLHE40 is associated with hypoxia‐related stress and glucose metabolism in PCa tumor‐associated neutrophils.[7] However, the roles and molecular mechanisms of BHLHE40 in PCa tumor cells have not yet been characterized. Here, BHLHE40 is linked to neoplasm.