BHLHE40 and posterior cortical atrophy: By evaluating the intersection of genes in groups of differentially expressed transcription factors from mRNA‐seq of the PAAD dataset in TCGA, H3K27ac CUT&Tag analysis of the enhanced binding sites (Figure S1C,D, Supporting Information), and ATAC‐seq of upregulated accessibility‐enhanced regions (Figure S1E, Supporting Information) in PCa organoids, a transcription factor (BHLHE40) was identified for further investigation (Figure 1A, Table S1, Supporting Information).