The behavior of PCa cells is highly dependent on master regulators, which are acquired in multi‐step tumorigenesis over long‐term exposure to high‐risk factors, and remains critical to the increased viability and proliferation of cells in a fully neoplastic state.[1] The activation of SREBF1 has been reported in numerous cancer types and is associated with enhanced cell proliferation, migration, invasion, metastasis, and chemotherapeutic resistance.[10, 32] SREBF1 enhances the fatty acid desaturation capacity of cancer cells via SCD1‐mediated desaturation. Here, SCD is linked to cancer.