As mentioned previously, insulin signaling via PI3K‐AKT‐mTORC1‐SREBF1 is a critical anabolic pathway for tumor cells to regulate lipogenesis in response to a nutrition‐deprived state.[10] Herein, we found that the mTOR signaling pathway also upregulates the expression of BHLHE40, a transcription factor required for the induction of SREBF1 mRNA in rodent liver.[21] However, the mechanism underlying the effects of BHLHE40 on SREBF1 expression remains unknown in PCa. The gene discussed is BHLHE40; the disease is neoplasm.