CAMK2G and diabetes mellitus: Furthermore, the 3′,4′-dihydroxyflavonol (DiOHF), a synthetic flavonol, was shown to alleviate diabetes-induced vascular dysfunction [166] and to modulate the p38 MAPK and JNK signaling cascades through inhibition of CaMKII with a potency (IC50 0.25 μM) that is superior to that of the well-established CaMKII inhibitor, KN-93 (IC50 3.3 μM) [167].