In contrast, biallelic inactivation of BRCA1 and RNF43 was also present in the CRC from person 010 with the tumor demonstrating characteristics of the serrated pathway (BRAF p.V600E mutation and high levels of CIMP), suggesting that for this tumour tumorigenesis may have been driven by RNF43 deficiency. The gene discussed is RNF43; the disease is colorectal carcinoma.