Of note, a study by Taupin et al. [15] identified a germline nonsense variant in RNF43 (c.394 C>T p.Arg132Ter) in two siblings affected with SPS, one developed CRC and a study by Yan et al. [17] identified a germline splice site variant (c.953-1 G>A) in RNF43 carried by six people from the family. This evidence concerns the gene RNF43 and colorectal carcinoma.