In this study, the diagnostic efficacy of the three signature genes for PC was also analyzed, and the results showed good diagnostic efficacy of COL10A1/FAP/FN1 for PC (ROC-AUC > 0.9) in both datasets GSE15471 (Fig. 3L–N) and GSE62165 (Fig. 3O–Q). This evidence concerns the gene COL10A1 and pachyonychia congenita.