ALX4 and frontonasal dysplasia: Mutations in genes encoding the ALX homeodomain-containing transcription factors (ALX1, ALX3 and ALX4) are associated with frontonasal dysplasia and produce midfacial phenotypes in vertebrate species (Beverdam et al., 2001; Iyyanar et al., 2022; Lakhwani et al., 2010; Lyons et al., 2016; McGonnell et al., 2011; Mitchell et al., 2021; Qu et al., 1999; Yoon et al., 2022).