The DMPtNPS@cGAMP + RT group exhibited a significant increase in anti‐tumor cytokines, namely IFN‐γ, IFN‐α, IFN‐β, TNF‐α, and IL‐2, and a more pronounced decrease in pro‐tumor cytokines, including IL‐1β, IL‐10, IL‐4, and TGF‐β, as measured by ELISA kits, in comparison to the other treatment groups (Figure 7I and Figure S24, Supporting Information). This evidence concerns the gene IFNB1 and neoplasm.