CD8A and neoplasm: On one hand, it can enhance antigen presentation, DC activation, and anti‐tumor CD8+T cell responses via ICD.[6, 24, 26] On the other hand, it can also induce immunosuppression through cytokines like TGF‐β,[42] which contributes to radioresistance.[27] Catalytic radiosensitizers can enhance the bidirectional remodeling effect of RT on the TiME, but cannot reverse the negative side effect of RT.