HMGB1 and neoplasm: Besides the classical pathways, studies have reported that the activated caspase‐4/5/11 and activated caspase‐3 in the presence of gasdermin E (GSDME) protein can also effectively induce the occurrence of pyroptosis.[39] What's more, Ansara's group and Liu's group jointly showed that pyroptosis not only effectively killed tumor cells, but also caused strong immunogenic cell death (ICD) to produce anti‐tumor immune activity via the release of damage‐related molecular patterns (DAMPs, e.g., ATP, calreticulin (CRT) and high mobility group protein B1 (HMGB1)), which were published in Nature.