Ding et al.[127] constructed a zinc‐organometallic framework vaccine (ZPM@OVA‐CpG) by self‐assembly, and illustrated that Zn2+ released from the vaccine significantly enhanced the infiltration and killing of CD8+ T cells by up‐regulation of the matrix metalloproteinase‐2 activity and degradation of tumor extracellular matrix, besides the activation of cGAS‐STING signaling pathway. Here, CGAS is linked to neoplasm.