Furthermore, if albumin is known to strongly associate with inorganic nanoparticles [15], it also contributes to some preferential accumulation in tumor and tumor cells through some receptors such as glycoprotein receptor Gp60 or Secreted Protein Acidic Rich in Cysteine (SPARC, also known as osteonectin; or basement-membrane-40, BM-40), whose overexpression is often associated with tumor growth, metastasis, and aggressiveness [17,18], a multifunctional glycoprotein that modulates the interaction of cells with the extracellular environment [19]. This evidence concerns the gene SPARC and neoplasm.