Some Toll‐like receptor ligands, such as imiquimod, a TLR7 agonist, and CpG, a TLR9 ligand, can directly induce apoptosis of TLR positive tumor cells, or enhance tumor‐infiltrating innate immune cells and tumor specific T‐cell functions.69, 70, 71, 72, 73, 74. The gene discussed is TLR7; the disease is neoplasm.