To further investigate the secretion of cytokines under various Teff/Treg ratios, we found that both the proinflammatory cytokine IFN-γ and the antiinflammatory cytokine IL-10 exhibited higher concentrations in the culture supernatant during gout flare compared with gout remission (Figure 4, H and I). The gene discussed is IFNG; the disease is gout.