By comparing the information flow between gout flares and remission, we identified that 15 of 42 pathways were highly active during gout flares, including 9 pathways involved in inflammatory and immune responses, such as CCL, IL-16, MHC-II, CLEC, GLAECTIN, ITGB2, and ALCAM (Supplemental Figure 8A). The gene discussed is IL16; the disease is gout.