Tumor cell gene expression also changed significantly in mANK-101–treated animals, with increased Stat1, Cxcl9, and Cxl10 (all consistent with IFN-γ signaling), as well as increases in Cd74, MHC alleles, and proteasome components, indicating increased antigen processing and presentation (Figure 6F). This evidence concerns the gene IFNG and neoplasm.