CCND1 and melanoma: Human malignant melanoma G361 cells were studied in vitro with esculetin, and the results showed that esculetin (0–80 μg/mL) causes apoptosis and nuclear shrinkage and fragmentation in G361 cells by raising levels of p21, p27, Bax, and active caspase 3, while lowering levels of cyclinD1, procaspase 3, and PARP.24