IL22 and colitis: On the other hand, ILC3s are known as the main producers of type 3 cytokines IL-17A and IL-22 to play a significant role in the development of colitis.21 Therefore, to definite the functional cell subsets where ILC3s mediate the anti-inflammatory effects of 12-KLCA, we performed the in vitro sorting for the colonic ILC3s from all mice (Figure 9c).