Interestingly, it seems that tRNAs and control regions (CR) display higher heteroplasmy levels in healthy controls than in leprosy patients, while protein-coding genes have a prominent heteroplasmy variation in the BT subgroup with a widespread pattern in comparison with BL and LL in all OXPHOS protein-coding genes (MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-CYB, MT-CO1, MT-CO2, MT-CO3, MT-ATP6 and MT-ATP8). This evidence concerns the gene MT-CYB and leprosy.