It is notable that all three bvFTD individuals with confirmed TDP-43 type C pathology fell into the Limbic-predominant subtype, which aligns with a staging system of brain atrophy in TDP-43 type C with early involvement of amygdala, medial and lateral temporal cortex, and temporal pole, followed by later involvement of insula [66]. This evidence concerns the gene TARDBP and Brain atrophy.