As shown in Fig. 1A, LEF1-AS1 was significantly downregulated in the RA synovial tissues compared to the normal synovial tissues, which was accompanied by the upregulation of miR-30-5p (Fig. 1B) and downregulation of PIK3R2 (Fig. 1C-E). This evidence concerns the gene PIK3R2 and rheumatoid arthritis.