ADAMTS7 and coronary artery disorder: Certainly, a large study [48] with approximately 60 919 CAD cases and 80 243 controls revealed that the protective effect of ADAMTS7 gene polymorphism (rs7178051) on CAD was weakened by environmental factors (5% lower CAD risk in smokers; 12% lower CAD risk in nonsmokers) compared to nonsmokers (12% lower risk), which showed the gene‒environmental interaction effects on CAD risk from another aspect.