This pattern included KISS1, FREM2, and ECM1. Secondly, the U-shape pattern depicted the tumor with the lowest level of expression and high expression in the far tissue, including FST, TBX1, and TMPRSS2. Lastly, a group of genes displayed the highest expression at 1-cm distance and the lowest at the tumor, contributing to the crater shape graph. Here, FREM2 is linked to neoplasm.