The top six upregulated gene sets in primary cancer by DGSS included fibrosis, cell motility, matrix metalloproteinase (MMP) remodeling, basement membrane, collagen family, and lysyl oxidase (LOX) remodeling at DGSS 9.84, 8.43, 7.79, 7.71, 7.55, and 7.20, respectively. The gene discussed is LOX; the disease is cancer.