Conversely, LAG3 mRNA expression was lower in the following: colon cancer (P < 0.001), kidney chromophobe (P < 0.001), liver cancer (P < 0.001), prostate cancer (P < 0.001), rectal cancer (P < 0.01), thyroid cancer (P < 0.05), and endometrioid cancer (P < 0.001), than in normal tissues (Fig. 1). This evidence concerns the gene LAG3 and malignant colon neoplasm.