LAG3 mRNA expression was higher in breast cancer (P < 0.001), esophageal cancer (P < 0.001), head and neck cancer (P < 0.001), kidney clear cell carcinoma (P < 0.001), lung adenocarcinoma (P < 0.001), and lung squamous cell carcinoma (P < 0.001) than in normal tissues. This evidence concerns the gene LAG3 and head and neck cancer.