LAG3 mRNA expression was higher in breast cancer (P < 0.001), esophageal cancer (P < 0.001), head and neck cancer (P < 0.001), kidney clear cell carcinoma (P < 0.001), lung adenocarcinoma (P < 0.001), and lung squamous cell carcinoma (P < 0.001) than in normal tissues. The gene discussed is LAG3; the disease is clear cell renal carcinoma.