It is called significant in 21 out of 39 histology types, including ColoRect-AdenoCA, Lymph-BNHL, Liver-HCC, and Panc-AdenoCA. Furthermore, our significant driver list for each indication overlaps the known cancer drivers in that indication. We identified candidate genes CDKN2A in HCSCC (Head and Neck Cancer), which is a known tumor suppressor and whose inactivation has been well studied in HCSCC [44]. Here, CDKN2A is linked to cancer.