BCL2 and cancer: Upon analysis, we discovered several overlapping genes of which variants were listed as potential cancer-associated genes in the other papers: Variants in BCL2 (Lymph-BNHL), SRSF2 (Lymph-BNHL) and TMEM129 (Thy-AdenoCA) were listed among top 1000 synMICdb variants, and we observed 3 exact BCL2 mutations in 5 unique patients in our dataset were within the top 1% in synMICdb (Additional file 3: Table S4).