To further examine the mechanism through which colchicine inhibits the proliferation of neutrophils in BM, we explored the role of the S100A8/A9-NLRP3-IL-1β signaling axis, which has been reported to regulate granulopoiesis and improve cardiac function in mouse myocardial infarction models [19]. This evidence concerns the gene IGKV1D-22 and myocardial infarction.