We evaluated the relationship between the expression of CD4 and CD8A genes and the target gene NSD2 in PCa using the GEPIA database, and the analysis showed that the expression of NSD2 was strongly correlated with the expression of CD4 (Cor = 0.26, P = 4.8e−11) and CD8A (Cor = 0.19, P = 1.7e–6), and the levels of CD4 and CD8A were closely correlated (Cor = 0.73, P = 5.6e−91) (Fig. 4A–C). Here, CD8A is linked to posterior cortical atrophy.