NSD2 protein was expressed in the nucleus, with 91.2% (52/57) positive expression of NSD2 in 57 PCa, 5.9% (2/34) positive expression of NSD2 in 34 BPH and 61.1% (22/36) in 36 PIN (Fig. 2C). The gene discussed is NSD2; the disease is posterior cortical atrophy.