The expression of TOB1 in tumor tissues distinctly differed from that in normal tissues with higher expression levels in breast invasive carcinoma (BRCA), while lower expression levels in HNSC, kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD) and thyroid carcinoma (THCA) (Fig. 3A). Here, TOB1 is linked to prostate adenocarcinoma.