For example, TOB1 predicted the prognosis in KIRC, LGG, MESO, PAAD, PCPG, PRAD, SARC, UCEC and UVM patients, and TOB2 predicted poor prognosis in COAD, GBM, KIRC, LGG, PAAD patients. The gene discussed is TOB2; the disease is glioblastoma.