Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by memory impairment, cognitive deficits, and behavioral abnormalities caused by pathological changes such as β-amyloid (Aβ) deposition, formation of neurofibrillary tangles with hyperphosphorylated tau protein, and uncontrolled microglia activation in the brain1,2. Here, MAPT is linked to Alzheimer disease.