More than 7000 genes were enriched in our analysis, and upon applying the filter (exclusively in breast cancer and Padj < 0.05), only 250 genes showed to have significant enrichment scores with TNBC (Fig. 2b), and genes such as E2F2, EGFR, PTEN, STAT3, BCL2, HOXA9, and AGO2 shown to have higher log2FC with a padj-value and betweenness score in the enriched network (Fig. 2b). The gene discussed is E2F2; the disease is breast cancer.