APOA2 and obesity due to melanocortin 4 receptor deficiency: The interactions between CEPT and APOA2 SNPs showed augmented predictive power among the groups (− 11.45% mean BMI change for the best response group vs. + 2.62% mean BMI change for the worst response group), which were associated with changes in obesity-related phenotypes after lifestyle modification (dCBT-O).