CCL5 and neoplasm: This effect is attributed to its ability to repolarize TAMs to the M1 phenotype through NLRP3 activation, which augments the secretion of the chemokines CCL5 and CXCL10 by M1 macrophages, thereby remodeling the tumor immune microenvironment from “cold” to “hot” and finally increasing the infiltration of activated CD8+ T cells.