Notably, there was no significant difference in the proportion of human CD68 + CD11B+ or murine F4/80 + CD11B+ total macrophages, based on flow cytometric analysis of tumor tissues in both the humanized CD34+ and C57BL/6 mouse models, suggesting that APG-2575 does not influence the overall infiltration of macrophages (Supplementary Fig. S5J). The gene discussed is CD34; the disease is neoplasm.