To further explore whether APG-2575 can induce a decrease in the population of M2 macrophages by promoting macrophage apoptosis, we treated macrophages with LPS + IFN-γ, which induces M1 macrophage polarization, and IL-4, which induces M2 macrophage polarization, as well as with conditioned medium (CM) from different tumor cells, which induces differentiation into TAMs. Here, IFNG is linked to neoplasm.