FGFR1 and FGFR3 expression was determined via IHC on the primary patient tumour, PDXs and PDXOs and very low expression of FGFR1 and FGFR3 were noted in those with high FGFR2c expression (Supplementary Fig. 8a, b) confirming that the FGF2/FGFR2c autocrine loop is the target of BGJ398 in these models. The gene discussed is FGFR3; the disease is neoplasm.