EMX1 and hepatocellular carcinoma: A 339 bp DMR in RSPH9 did not contain 4 CpG sites with sufficient specificity (> 0.005 meth-diff) as shown in Supplementary Fig. 1A. An example of a DMR selected for further development is EMX1. The 386 bp DMR in EMX1 has two regions with ≥ 0.005 meth-diff between non-HCC and HCC and with more than 4 CpG sites positioning within 70 bp (Supplementary Fig. 1B).