RPS6 and non-small cell lung carcinoma: Of note, inhibition of AMPK using Compound C was able to rescue the mTOR activity in NSCLC-educated T cells, showing increased levels of p-S6 and p-AKT that were accompanied with reduced p-AMPKα (Fig. 2F, S3A), assigning AMPK hyperactivation as responsible for the mTOR inactivation in those T cells.