CD4 and non-small cell lung carcinoma: To understand how human NSCLC could drive AMPK hyperactivation, we detected the intracellular energy status in NSCLC-interacted T cells and found that pre-incubation with NSCLC caused an obvious reduction in ATP levels as well as marked elevations of ADP/ATP and AMP/ATP ratios in CD4+ T cells (Fig. 3A), providing the energy status for AMPK activation.