TREM2 and Parkinson disease: A search for rare (gnomAD overall allele frequency [AF] <0.01) deleterious variants in 74 disease-associated genes (Supplementary Table 2) identified variants in 8 genes (Table 2), including one in TREM2 (rs2234253) in patients 2 and 5 (Table 1B) both of DR ethnicity with tremor predominant PD; and one in CTSB (rs28605689) in patient 6 (Table 1B) with postural instability and gait disorder (PIGD).