IL1B and acute myeloid leukemia: To query whether the DEGs identified in Tet2-KO relative to WT HSCs at steady and pro-inflammatory states are also relevant to TET2 mediated-acute myeloid leukemia (AML) primary samples, we used a gene signature for vehicle and IL1β treated mice using the top 100 upregulated DEGs by significance in Tet2-KO relative to WT HSCs.