Genes within the leading edge include the core inflammation and self-renewal signatures such as phosphatases (DUSP1), AP-1 members (JUN, JUND, FOS), and multiple other transcription factors (KLF2, KLF6, EGR1), suggesting these may also be relevant for TET2-dependent primary AML (Supplementary Fig. 8f). The gene discussed is DUSP1; the disease is acute myeloid leukemia.