CASP3 and colorectal carcinoma: Moreover, compared with the HR488B treatment alone group, both the inhibitory effects on Bcl-2 and the stimulative effects on cl-PARP, cl-caspase 3, and Bax were remarkably diminished in the NAC and HR488B combined treatment group (Fig. 5l, m), which confirmed that HR488B indeed triggered the apoptosis of CRC cells by enhancing ROS levels.