We found no evidence for increased abundance of CBFB exons 1–5 in CBFB::MYH11 AMLs, relative to RUNX1::RUNX1T1 or NPM1c-mutated AMLs (Figure 8E), suggesting that the transcriptional activity of the CBFB locus is not substantially altered by the fusion in primary AML cells. This evidence concerns the gene RUNX1 and acute myeloid leukemia.