Consistent with the murine data, RUNX1 was significantly overexpressed in CBFB::MYH11 AMLs (mean expression 981.4 ± 236.1) relative to CD34+ HSPCs (175.9 ± 39.06), RUNX1::RUNX1T1 AMLs (641.7 ± 103.3), PML::RARA acute promyelocytic leukemias (APLs) (532.0 ± 197.6), or NPM1c-mutant AMLs (553.5 ± 197.6) (Figure 7C, left). This evidence concerns the gene RARA and acute promyelocytic leukemia.