While some DEGs relative to healthy donor CD34+ cells were shared between the 2 AMLs, most DEGs were also shared with NPM1c-mutated AML, suggesting that they may represent AML-specific dysregulated genes, rather than a CBF-specific AML transcriptional signature (Supplemental Figure 6, B and C, and Supplemental Tables 8–11). Here, CD34 is linked to acute myeloid leukemia.