Interestingly, RUNX1::RUNX1T1 also interacted with proteins in the cohesin complex (STAG1, STAG2, and RAD21); although mutations in genes encoding cohesin complex proteins commonly occur in RUNX1::RUNX1T1 AML (48–50, 52), direct physical interactions between RUNX1::RUNX1T1 and cohesin proteins have not previously been reported to our knowledge. The gene discussed is RUNX1; the disease is acute myeloid leukemia.