ChIP-Seq studies in cell lines (83, 84) and transformed murine leukemias (40) using CBFB and MYH11 antibodies have reported CBFB::MYH11 enrichment at specific target gene sites; however, CBFB::MYH11 binding was associated with upregulated genes (40) or both up- and downregulated genes (83, 84), which is inconsistent with the hypothesis that this fusion creates a transcriptional repressor phenocopying the mechanism of RUNX1::RUNX1T1. Here, RUNX1T1 is linked to leukemia.