In this study, we examined the protein interactomes of the 3 favorable-risk AML oncofusion proteins, PML::RARA, RUNX1::RUNX1T1, and CBFB::MYH11, using primary murine hematopoietic cells transduced with a retroviral TurboID vector system developed in our laboratory. Here, RUNX1 is linked to acute myeloid leukemia.