ALPK1 and benign spiradenoma: Remarkably, in a cohort of 30 unrelated patients with spiradenoma or spiradenocarcinoma, 7 of the 16 spiradenoma patients and 4 of the 14 spiradenocarcinoma patients were found to have the same Val1092 to Ala mutation located within the protein kinase domain of ALPK1 (18).