Their AUC values ranged from 0.707 to 0.942; however, the current clinical diagnostic biomarkers (carcinoembryonic antigen (CEA) and cancer antigen 19–9 (CA 19–9)) for colorectal cancer ranged from 0.672 to 0.707 and 0.574 to 0.617, respectively. The gene discussed is CEACAM5; the disease is colorectal cancer.