Among subtypes of AML, complex karyotype AML had higher cell-surface expression of PD-1H than t(8;21) and t(15;17) AML, suggesting poor-risk AML, such as complex karyotype, tends toward higher expression of PD-1H than favorable-risk AML, such as t(8;21) and t(15;17) (Supplemental Figure 2). The gene discussed is VSIR; the disease is acute myeloid leukemia.