The lymphocytic infiltrates included CD4+ and CD8+ T cells with an effector/memory phenotype (CD44hiCD62Llo), including antigen-experienced (CD49dhi) and activated (CD69hi) CD8+ T cells, as well as those with terminally differentiated (KLRG1hi) and exhausted (PD-1hiTIM-3hi) phenotypes (Figure 10F and Supplemental Figure 10), as seen previously in humans with NASH (32, 54–56). Here, CD8A is linked to metabolic dysfunction-associated steatohepatitis.