We found that Nox4, Sod1, Sod2, Cat, Nfe2l2, and Nqo1 mRNA levels were increased in hepatocytes from HFD-FPC mice with mild NASH with minimal inflammation and no appreciable fibrosis (Figure 14G), but tended to decline in hepatocytes from mice with advanced NASH with comparable levels of steatosis but more inflammatory foci and overt fibrosis (Figure 14G). This evidence concerns the gene SOD2 and metabolic dysfunction-associated steatohepatitis.