ALB and steatosis: Liver weights were also increased in HFD-fed mice (Figure 8C; Supplemental Figure 6C) but not chow-fed Alb-Cre Nox4fl/fl mice (Supplemental Figure 5E), and this was accompanied by increased steatosis, as assessed by H&E histology for lipid droplets and staining for neutral lipids with Oil Red O (Figure 8D and Supplemental Figure 6D); steatosis was not evident in chow-fed Alb-Cre Nox4fl/fl mice (Supplemental Figure 5F).