The rate of glucose disappearance (RD), a measure of muscle and adipose tissue glucose uptake, was reduced in clamped Alb-Cre Nox4fl/fl mice (Figure 9D), whereas endogenous glucose production (EGP) in clamped Alb-Cre Nox4fl/fl mice was increased (Figure 9E and Supplemental Figure 7, F and G), consistent with hepatic insulin resistance. Here, ALB is linked to Insulin resistance.