Therefore, NAFL, but not obesity per se, was accompanied by the increased expression of NFE2L2 targets genes, including NOX4, which encodes a ROS-producing enzyme, and NQO1, SOD2, and CAT, which encode key antioxidant defense enzymes, but these declined with more advanced disease and fibrosis. Here, NFE2L2 is linked to obesity due to melanocortin 4 receptor deficiency.