NOX4 and metabolic dysfunction-associated steatohepatitis: Hepatocyte NOX4 deletion in high-fat diet–fed obese mice, which otherwise develop steatosis, but not NASH, resulted in hepatic oxidative damage, inflammation, and T cell recruitment to drive NASH and fibrosis, whereas NOX4 overexpression tempered the development of NASH and fibrosis in mice fed a NASH-promoting diet.