DAMs included only 3 upregulated (tetradecanoic acid, tetradecenoic acid, and hexadecenoic acid) and 4 downregulated (L-cysteine, glutathione, 2,3-phospho-D-glycerate, and UTP) metabolites in platelets from JAK2-mutant ET patients (Supplemental Figure 5H). The gene discussed is JAK2; the disease is essential thrombocythemia.