PLEKHA1 and atherosclerosis: For the mouse-specific liver atherosclerosis pathways, Ptprb, Kdr, Oit3, and Cyp4b1 were found to be the top KDs for a VEGF/VEGFR module; Tmem43, Mtmr11, Plekha1, and Scnn1a were the top KDs of a module related to amino acid metabolism (arginine and proline metabolism, glycine, serine, threonine metabolism) and cardiac EGF pathways (Figure 4D).