In liver, human-specific CAD pathways include immune system terms (interferon alpha/beta signaling, BCR signaling, and MHC class II antigen presentation), carbohydrate and BCAA metabolism, lysosome, neurotrophin signaling, and axon guidance pathways, among which BCAA and carbohydrate metabolism pathways were found to be shared between species in the vascular tissue-based analysis. This evidence concerns the gene ARID4B and coronary artery disorder.