TNF and scleritis: Monoclonal antibodies against TNF-α (all except Etanercept), IL-1 inhibitors (Anakinra), IL-6 inhibitors (Tocilizumab), and anti-CD20 (Rituximab) targeted-drugs have been shown to control inflammation and reduce scleritis flares, allowing for a corticosteroid-sparing effect [5, 8, 10, 11].